with a blunted response to rewarding stimuli, in general, may require larger drug amounts or more potent drugs for reinforcement, and thus, be more susceptible to the development of severe addiction69. Such an interpretation is consistent with evidence that unaffected offspring of alcohol dependent individuals and adolescents who later develop problematic drug use have reduced VS response to anticipatory cues of monetary reward70,71 as well as evidence that individuals who are less sensitive to the intoxicating effects of alcohol are at greater risk for dependence72.
