Finally, our finding of elevated odds of rVUS in adolescent cannabis users persisted even when they were only compared to their late-onset user co-twins (i.e. both twins had initiated use but at different ages). Even though the number of discordant MZ pairs was modest, these significant results suggest that women who use cannabis prior to age 17 are more likely to report rVUS relative, not only, to those who never use cannabis but also when compared to later-onset users. Thus, delaying the onset of cannabis use in women may have an appreciable impact on likelihood of rVUS.
