DS-epi1 shRNA-a cells as compared to control cells (Fig. 2E). The remaining IdoA upon DS-epi1 downregulation could be formed by the action of DS-epi2, the mRNA expression of which increased 5-fold in DS-epi1-downregulated cells (Fig 2G), while, as expected, DS-epi1 mRNA was decreased by approx. 90 % (Fig. 2F).
