In the first analysis, we estimated the fraction of SNPs for which the signs of the WF estimates were concordant with the signs of the estimates obtained from a GWAS identical to our primary subjective well-being GWAS except with the four family cohorts excluded. For the 112,884 approximately independent SNPs considered, we found a sign concordance of 50.83%, which is significantly greater than 50% (p = 1.04 × 10−8). Under the null hypothesis of no population stratification, the observed sign concordance matches the expected rate after winner’s curse adjustment nearly perfectly, 50.83% (Supplementary Fig 9).
