The close phylogenetic relationship and the high degree of homology between human and non-human primate (NHP) brains, genes, and behaviors make NHP studies indispensable for understanding the neuronal substrates of human behavior, as well as neurological, neurodegenerative, and psychiatric diseases.21 Here, we used snRNA-Seq and Fluorescent In-Situ Hybridization (FISH) to characterize the transcriptional and anatomical diversity of MSNs and closely related neurons. The resulting cell-type-specific gene expression patterns provide insights into MSN functions and indicate potential molecular access points for cell-type-specific applications of genetically coded tools to primate brains, in scientific or translational settings.
