In EA and Hispanic subjects in the CADD, the SNPs were somewhat correlated with an r2 > 0.50, with the exception of rs9291283 (Figure 2A and 2B, respectively). As mentioned previously, rs279858 and rs279871 were highly correlated at r2 > 0.80. Similar LD patterns were observed in EAs and Hispanics in the GADD sample as in the CADD sample (Figure 3A and 3B, respectively), which is in agreement with the similarity in allele frequencies. In addition, the r2 value between rs9291283 and all other SNPs examined was less than 0.10, indicating this SNP represents an independent signal in the gene.
