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Chunk #34 — Discussion

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Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.
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attempted to address this issue by also implementing a multi-ethnic polygenic scoring approach (Márquez-Luna et al. 2017), the predictive power of the polygenic score constructed using this approach in the African ancestry subsample was still severely attenuated when compared to the results observed in the European ancestry subsample. Newer statistical methods and approaches to better account for differences in allele frequencies and LD patterns in order to calculate polygenic scores across populations are under development (e.g., Liang et al. 2020). However, there is a critical need to prioritize diversity and increase representation of non-European population in genetic research in order to ensure that all racial/ethnic groups benefit equally from advances related to genetic findings (Martin et al. 2019).