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Chunk #26 — Results — fMRI — Stimulus Effects

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Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers.
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Within the a priori ROIs, there were statistically significant Odor main effects (reflecting significant BOLD differences between AO and ApCO) in the left (F= 13.54, p ≤ 0.001) and right (F= 9.62, p ≤ 0.005) mPFC ROIs, and in the left (F= 15.76, p ≤ 0.001) and right (F= 15.99, p ≤ 0.001) vmPFC ROIs. Neither the ventral striatum nor the caudate heads showed a significant Odor main effect (p’s > 0.50), but there was a significant Odor effect in the VTA (F= 5.16, p ≤ 0.05). In all cases, these significant main effects reflected a greater AO than ApCO response (p’s 0.005 for frontal ROIs, p ≤ 0.05 for the VTA).