The results of this study suggest that an increased sensitivity to E2-based epigenetic reprogramming may represent a molecular mechanism of predisposition to PPD risk. Future studies will be needed to rigorously test this hypothesis and track epigenetic changes through the course of pregnancy in women at risk and not at risk for PPD. The investigated population was in women with a previous history of mood disorders; however, studies investigating the efficacy PPD prediction in the general population will need to be determined. Accurate prediction of PPD status will enhance the clinical management of psychiatric treatment during the course of pregnancy.
