administered diaze-pam during the withdrawal periods in order to assess the role of possible GABAA receptor withdrawal-related perturbations, the attenuation of the ethanol-induced CTA was not dissimilar between diazepam-treated and control animals, suggesting that GABAA receptor perturbations during withdrawal were not playing a role in the attenuation of CTA. However, adult mice that were exposed to only diazepam during the adolescent period showed the same attenuated CTA as adult mice exposed to only ethanol during adolescence. Thus, the rewarding and aversive properties of ethanol, and therefore ethanol self-administration, in adulthood are related to the interaction of these drugs with a developmentally dynamic GABAergic system.
