Chunk #14 — Materials and methods — Statistical analysis

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Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls.

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In all analyses, mixed models were run separately at each vertex. We first established the relationship between Val dose and cortical maturation in HCs, by modeling CT for ith family's jth individual's kth time-point as: CTijk=Intercept+di+dij+β1(sex)+β2(mean age)+β3(Val dose)+β4(mean age*Val dose)+eijk