Finally, because FH-Alc is likely to be associated with major depressive disorder, and obesity is also a correlate of major depression and/or other mood disorders in the United States,30, 31 life-history of major depression was added to the models. This resulted in modest, and non-significant changes in the association between FH-Alc and obesity for both genders in both surveys. In these final models, the adjusted odds ratios for women were 1.30 (95% CI: 1.19, 1.43) in the NESARC, and 1.00 (95% CI: 0.91, 1.10) in the NLAES; difference p<0.0001. Hence the association between FH-Alc and obesity among women remained highly significant in the NESARC (p<0.0001), and the difference in the association between the NLAES and NESARC remained significant for women (p<0.0001). A modest association between FH-Alc and obesity remained for men in the NESARC after adjustment (OR=1.11; 95% CI: 1.01, 1.23, p=0.02); this was a slight, but non-significant increase over the NLAES (OR=1.02; 95% CI: 0.94, 1.11)
