causal tissue/cell type, which may be unobserved. Third, our focus on nearby SNPs prevents us from leveraging signal from regulatory SNPs that act at longer distances. Our approach is also fundamentally limited by the availability of gene expression data and cannot rule out the importance of a given cell type; for example, if the tissue/cell type that is most relevant for a disease occurs in a stage of development or under a stimulus that has not been assayed, then we may not identify enrichments in that tissue/cell type. We would also like to highlight that for most of these phenotypes there is likely not just one causal tissue/cell type, but many.
