We used the spectral decomposition (SNPSpD) method (Nyholt 2004) to estimate the minimum p-value required to keep experimental type I error < 0.05. This method is used as a correction for multiple testing for SNPs in linkage disequilibrium with each other. All Hispanic and EA family members were included to define a new p-value used to correct for multiple testing. The spectral decomposition was run using each sample separately to provide a corrected p-value for each analysis of the CADD, GADD, and CADD/GADD combined samples.
