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Chunk #38 — 4. Discussion

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Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.
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al., 2002; Sterneck & Johnson, 1998; Taubenfeld, Milekic, Monti, & Alberini, 2001). Thus, the A>G substitution on rs12720071 may potentially disrupt C/EBPbeta transcription factor binding, and leads to WM volume deficits and cognitive dysfunction among rs12720071-G-alleles carriers with heavy marijuana use.