al., 2002; Sterneck & Johnson, 1998; Taubenfeld, Milekic, Monti, & Alberini, 2001). Thus, the A>G substitution on rs12720071 may potentially disrupt C/EBPbeta transcription factor binding, and leads to WM volume deficits and cognitive dysfunction among rs12720071-G-alleles carriers with heavy marijuana use.