Having contacted all known 1936-born individuals living in Edinburgh and the surrounding area listed on the CHI (including the second letter to the first 1741 individuals invited), media advertisements were used to find any interested and eligible participants that may have been missed by this procedure. A call for volunteers was placed in a freely-distributed Edinburgh weekly paper in February 2007, and an advertisement was placed in an Edinburgh-based evening newspaper in March 2007. Due to the almost-blanket coverage of the CHI mailing, the response to the media advert was low, generating about 97 replies. These have been included in the numbers detailed above.