of multiple protein isoforms in a brain region-specific manner (Etheridge et al., 2009). Furthermore, our group has demonstrated that dynamin-1 establishes a strong physical interaction with the large conductance voltage- and calcium-activated potassium channel (BKCa), another major player in alcohol actions (Gorini et al., 2010). Interestingly, multiple miRNAs upregulated in human alcoholics, including miR-101, miR-135b, miR-140, miR-203, miR-34c-5p, miR-376, miR-454, miR-519b-3p, miR-580, and miR-586 (Lewohl et al., 2011), are predicted to target dynamin family members, which underscore the role that these proteins and respective targeting-miRNAs play in mediating alcohol actions.
