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Chunk #16 — Methods — Association analysis

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The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis.
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Association between SNP marker allele counts and copy number and SHAS scores were evaluated using a logistic regression model through the SAS statistical package testing for statistical inferences using a generalization of the standard linear model. Family ID and marker genotype were used as classification variables and the effects of copy number and genotype were modeled against the SHAS score. Genotypes were classified based in the count of the minor frequency allele.