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Chunk #50 — ONLINE METHODS — Cross-cohort genetic correlation.

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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We estimated the genetic correlation of EduYears across all pairs of cohorts with non-negative heritability estimates (Supplementary Table 22). We used bivariate LD Score regression39 implemented by the LDSC software with a European reference population, filtered to HapMap3 SNPs. The estimated genetic correlations of EduYears between each of our 933 pairs of cohorts is shown in Supplementary Table 23.