We generated RNA sequence data from post-mortem human dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) from brain banks at the Icahn School of Medicine at Mount Sinai, the University of Pennsylvania, and the University of Pittsburgh (Supplementary Table 1). To control for batch effects, multiple randomization steps were introduced and DNA and RNA isolation and library preparation were performed at one site (Supplementary Fig. 1A). Samples were genotyped on the Illumina Infinium HumanOmniExpressExome array (958,178 SNPs) and imputed using standard techniques with the 1000 Genomes Project as reference data11. These genotypes were then used to detect SNPs that have an effect on gene expression (eQTLs, expression quantitative trait loci), to estimate ancestry of the samples, and to ensure sample identity across DNA and RNA experiments. Ethnicity was similar between cases and controls (Caucasian 80.7%, African-American 14.7%, Hispanic 7.7%, East Asian 0.6%, Supplementary Figs. 1B, C). As expected3, SCZ cases inherited an increased number of common variant alleles previously associated with SCZ risk (P = 1.6 × 10−8, Supplementary Fig. 1D).
