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Chunk #17 — METHODS — TREATMENT STUDY

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The incentive salience of alcohol: translating the effects of genetic variant in CNR1.
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The analyses included 69 participants randomized to a 12- week trial of olanzapine (5 mg) or placebo. Participants completed baseline measures of demographics, personality, alcohol use, alcohol-related problems, and motivation for change. At 2 weeks, these participants completed a cue reactivity assessment that involved comparing reactivity between controls (eg, a nonalcoholic beverage such as Gatorade) and alcohol-related cues (eg, the preferred alcoholic beverage). During the control cue exposure, participants were asked to lift and sniff Gatorade without tasting it for 3 minutes. Participants completed measures of mood and craving before and after exposure. After a 5-minute relaxation period, participants repeated the cue exposure with their preferred alcoholic beverage and completed the same craving and mood measures. All the participants received 2 sessions of a brief, psychosocial intervention. These sessions occurred at the end of the baseline and cue reactivity sessions.