In a multiethnic sample representative of the U.S. population, we tested DNA sequence variants at 19 loci that had been discovered in individuals of European descent. We addressed the hypothesis that these same variants would relate to blood lipid traits in other ethnic groups. At five loci (CELSR2/PSRC1/SORT1, HMGCR, CETP, LPL, and APOA5), we found that the same variant identified in whites was nominally associated in both non-Hispanic blacks and Mexican Americans. At other loci, there was mixed evidence for SNPs by ethnic group.
