in the NTR cohort (which introduces additional noise due to heterogeneity between the cohorts, Supplementary Table 5).We separately used GCTA to estimate the heritability of height explained by all of the genes selected by each algorithm by constructing a GRM from the selected genes. In contrast to the risk score, this does not assume pre-defined weights on each gene but allows them to be fit by the REML model. Results were comparable, with only the TWAS-selected genes explaining significantly non-zero heritability (Supplementary Table 5).
