Genes highly associated with Parkinson’s disease and highly specific to cholinergic and monoaminergic neurons were significantly enriched in terms related to endosomes and synapses (Table S5). Similarly, genes highly specific to oligodendrocytes and Parkinson’s disease were enriched in endosomes. These results support the hypothesis that the endosomal pathway plays an important role in the etiology of Parkinson’s disease 40.
