Results are shown in Figure 4A. Using the MVL-MI-Canolty algorithm, there was a significant increase in alpha-gamma PAC over a large proportion of the comodulogram, between 40–100 Hz and 7–13 Hz, with a peak at 50–70 Hz amplitude and 9–10 Hz phase. This large area of significantly increased PAC is likely to reflect, in part, power increases in the gamma-band (Canolty et al., 2006). The alternative MVL-MI- Özkurt algorithm, which normalizes MI-values by the high-frequency oscillatory power, displayed a smaller area of significant coupling, with increased PAC between an amplitude of 50–70 Hz and phase of 10 Hz. There was also a similar cluster of significantly increased PAC between 9–11 Hz and 50–70 Hz using the PLV-MI-Cohen approach. The KL-MI-Tort results showed clusters of increased PAC between amplitudes of 50–100 Hz and phases of 9–10 Hz, but decreased PAC between amplitudes of 60–90 Hz and phases of 12–13 Hz. However, none of these clusters passed a significance threshold of p < 0.05 (two-tailed). Similar results were obtained after normalizing MI values with surrogate data (Figure 4B).
