Chunk #43 — Online Methods — Derivation of relationship between h2 and hγ2

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Leveraging population admixture to characterize the heritability of complex traits.

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In practice we do not know the effect size of every SNP and must make simplifying assumptions about their distribution in order to estimate FSTC. First consider a simple phenotypic model in which genotypic effect size βs is independent of ps,o and ps,1. Then