ALD and MLD are not very informative, since WM anomalies are essentially diffuse and can originate in any part of the brain. In these diseases there is no reported correlation between psychotic symptoms and a lobar predominance. In MS, two studies consistently demonstrated that demyelinization located in the temporal lobe were more common in patients developing psychosis.90,91 Contrary to what could be expected, frontal location is not very likely to be associated with psychosis. It is more frequently accompanied by depression in MS,92 but also in WM dementia (eg, in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL]).93,94 This could be a reminder of the hypothesis that links frontal lobe hypofunction to the psychomotor retardation shared by depression and schizophrenia.95
