50/53 datasets included individuals of European ancestry, while three datasets include individuals of Asian ancestry (1,836 cases, 3,383 controls). All individuals were ancestrally matched to controls. Information on genotyping, quality control and other data management issues may be found in the original papers describing these collections22,60. All sample collections complied with ethical regulations. Details regarding ethical compliance and consent procedures may be found in the original manuscripts describing these collections22,60.