Chunk #20 — Subjects and methods — Calculating statistical power for using public controls under cross array imputation scenarios

Source

Imputation across genotyping arrays for genome-wide association studies: assessment of bias and a correction strategy.

Embedded

yes

Text

R2 to proportionately reduce sample size to effective sample size (Pritchard and Przeworski 2001; Pasaniuc et al. 2012) due to imputation inaccuracy, and then used Elston’s Excellent Estimator (Tiwari et al. 2011) via the web tool Analytic Power Calculation (http://gwatestdriver.ssg.uab.edu/) to estimate power for a given sample scenario (at various α, β, and sample sizes) and level of imputation accuracy (average R2).