expression analysis to compare their expression levels in one cell type versus the rest of the other cell types using Wilcoxon Rank Sum test to determine if they are highly expressed in a particular cell type. The data met the assumptions of the statistical test used. For multiple testing correction, we used false discovery rate (FDR) adjusting for all 17,775 genes. We presented in Figure 2a only genes that had FDR p <0.05. Following the same approach, we determined if the 25 potentially causal genes from the meta-analysis of the discovery and replication depression PWAS are highly expressed in a particular cell type.
