Widespread supratentorial diminutions in FA (Pfefferbaum et al., 2006b) as well as reduced tract integrity in the genu and splenium of the corpus callosum and centrum semiovale (Pfefferbaum et al., 2006a; Pfefferbaum and Sullivan, 2005) are evident in adult alcoholism, consistent with splenium FA deficits among users here. Right inferior frontal FA deficits in MJ+ALC users also coincide with the reduced fiber coherence observed in prefrontal and orbitofrontal white matter of adult alcoholics (Harris et al., 2008). The strong negative relationship between lifetime alcohol consumption and FA in this region may indicate a common frontal vulnerability among adolescent and adult users.
