A second goal was to determine if the decrement in brain function associated with CD problems was also associated with a variant of the GABRA2 gene previously shown to promote risk for CD (35). More specifically, we asked whether CD problems and GABRA2 genotype would similarly enhance the changes associated with smoking or obesity. To accomplish the goal, an exploratory analysis was conducted in which the presence versus absence of 2 or more problems was replaced by presence versus absence of the genotype previously associated with conduct problems.
