test simulations uses a demographic history model with a range of possible values of strength of selection leading to different relationships between effect size and x. These simulations were designed to demonstrate the strengths of each methods under different effect-size distributions: the WSS is designed for effect sizes proportional to 1/x(1 − x), SKAT is designed for effect sizes proportional to beta density β(x; a1, a2) for prespecified a1 and a2, the C-alpha67 test is designed for effects going in opposite directions in the same region, while the VT test makes no assumptions about effect-size distributions.
