was stronger in young (≤30) individuals. In addition, although CHA did not show any interaction with 5-HTTLPR on any of the phenotypes, it had an important influence on the 5-HTTLPRxRLE interaction. Namely, in young subjects it sensitized towards the effect of RLE even if RLE was mild, when a combined multivariate outcome was used. In older subjects (>30) 5-HTTLPR was only relevant when more RLE were reported irrespective of childhood adversity. The results suggest that the modulatory effects of serotonin transporter gene variation on the risk of depression may involve different mechanisms in different age groups.
