strains would present a myopic picture that would not reveal that there are three distinct levels of H2-Eα mRNA expression among the 10 strains that we analyzed [7] (Figure 2). H2-Eα expression levels varied by 268-fold across the 10 strains, but only differed by 4.5 fold between the two strains used in the linkage study [3]. The novel enhancer element identified by analysis of 10 strains [7] would not have been found in the linkage study, and would be regarded as a false positive in the published modeling study [3].
