Chunk #28 — Discussion — Contrast with Interpretation of Results from the only Prior Study of ADH1B and Childhood Adversity Effects on Alcohol-Related Phenotypes
Although ADH1B variants are among those most consistently identified in genetic studies of alcohol phenotypes (e.g., Bierut et al., 2012, Carr et al., 2002, Gelernter et al., 2014, Kim et al., 2008, Li et al., 2011, Meyers et al., 2013a, Neumark et al., 2004, Park et al., 2013, Tolstrup et al., 2008), we know of only one previous GxE investigation of childhood adversity that examined ADH1B, a study based on a sample of 1,143 Israeli Jews (78.3% male) (Meyers et al., 2013b). The inclusion of a substantial number of African-Americans and women in this study allowed us to examine sex differences and determine the generalizability of their findings in another population. Meyers and colleagues found that the relative influence of rs1229984 on maxdrinks and AUD symptoms was greater among individuals exposed to adverse events in childhood than among those who were not exposed. Our results are only partially consistent with theirs. In addition to the fact that we observed an interaction only for AUD symptoms and Meyers et al. (2013b) found an interaction for both maxdrinks and AUD symptom phenotypes,
