a SNP in this region, rs1451240, was associated with reduced risk for nicotine dependence, measured using the Fagerstrom Test for Nicotine Dependence (FTND) [18]. The LD bin tagged by rs1451240 spans ~66 kb and several other alleles of SNPs in this bin have been associated with reduced risk for nicotine dependence, although no others are significant at the genome-wide level [18]. The data in Table 3 show that in EUR and AFR, four adjacent SNPs from this LD bin, including rs1451240, were present in sliding windows with extreme Tajima’s D values in AFR. These data suggest that these nicotine dependence-associated SNPs may be undergoing balancing selection or positive selection in these two populations.
