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Chunk #17 — RESULTS — Effects of SDPS on alcohol taking and alcohol seeking — Acquisition of operant alcohol SA

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Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.
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Analysis of the alcohol consumption data led to similar results; as in all three reinforcement schedules, the two SDPS groups gained higher number of rewards in comparison with controls (Figures 2C, S2; Tables S2, S3). The average number of inactive responses per session was similar between the three groups in all reinforcement schedules given, supporting the view that task responding was alcohol specific and excluding general psychomotor deficits long‐term following social defeat (Figure S2, Table S4). Together, the FR1 to 3 acquisition data reflected an SDPS‐driven escalation of responding for an alcohol reward, which persisted, and was even exaggerated under more demanding reinforcement schedules.