The main findings from the present sample of persons reporting low mood are: (1) current and past smoking predicted increased risk for SRO independently of demographics, psychiatric factors and prior SRO; (2) long-term smoking abstinence was associated with lower risk than persistent smoking; (3) new smoking due to relapse after a period of abstinence or to initiation of smoking by erstwhile never smokers was associated with an increased risk of SRO relative to persistent smoking; (4) prior SRO did not increase the risk of future smoking.