regulated by common substrates and closely associated endophenotypes governing the pathophysiology of alcohol dependence. MicroRNA miR-9, a post-transcriptional regulator of splice variation and neuroadaptations of alcohol tolerance (a hallmark of escalated alcohol drinking), targets a notable share of genes within Group1 (P = 9.17 e-04). Noteworthy targets of miR-9 include the BK potassium channel KCNMA1 and GAD1, components of neuronal excitability and alcohol behavioral phenotypes 46-48. These results further highlight the utility of the network-based approach to concurrently identify multiple disease relevant genes, an important tool given the multifaceted nature of alcohol use and other psychiatric disorders.
