Thus far, little is known on how the traditional and recently proposed methods for testing G × E interactions perform in the context of GWAS and whether they can be applied to meta- or cross-study analysis for discovery purposes. The latter is especially important, because in order to achieve the sample sizes required to detect small to modest interaction effect sizes, a cross-study collaborative approach may be the only option. Unlike other consortia, GENEVA is well positioned to apply these methods and in doing so we will finally have a better measure of their performance. Caveats to their application and interpretation might also be uncovered which, in turn, will aid in further method development and optimization.
