The ability of h2 to predict OMIM/NHGRI designation may suggest new approaches to augment association mapping, as current approaches generally focus on the sequence context of associated SNPs, rather than the genes themselves. The ability to detect heritability only in expressed genes somewhat complicates interpretation, given the higher average expression in high-density clusters, and lack of information for genes not expressed in this tissue. Critically, full elucidation of these relationships may be possible only with careful cross-tissue eQTL analysis of a large number of individuals. 15
