Chunk #1 — Reverse causation

Source

Cannabis controversies: how genetics can inform the study of comorbidity.

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yes

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Alternatively, it is possible that psychiatric conditions cause cannabis (or other drug use, Figure 1B) as has been proposed, for example, in the self-medication hypothesis (21) which posits that drug use develops in an attempt to ameliorate the negative states associated with common mental health problems such as depression (22).