Bivariate LDSR showed nominally significant (P < 0.05) genetic correlations (rG) between meta-analyzed MDD and 28 of the 200 health-related traits assessed. Of these, 8 traits survived multiple testing correction: neuroticism (rG(SE) = 0.67(0.07); P = 7.06 × 10−21), depressive symptoms (rG(SE) = 0.81(0.09); P = 1.72 × 10−19), subjective wellbeing (rG(SE) = −0.56(0.08); P = 9.12 × 10−13), age at first birth (rG(SE) = −0.35(0.05); P = 1.92 × 10−10), major depressive disorder (rG(SE) = 0.67(0.12); P = 4.57 × 10−8), PGC cross-disorder analysis (rG(SE) = 0.46(0.09); P = 8.60 × 10−8), bipolar disorder (rG(SE) = 0.32(0.08); P = 4.35 × 10−5) and systemic lupus erythematosus (rG(SE) = 0.28(0.08); P = 8.00 × 10−4). These findings are consistent with previously reported, well-established relationships between MDD and neuroticism63–65, bipolar disorder51,66, PGC cross-disorder66, depressive symptoms7,67 and subjective well-being68. Relationships between MDD and age at first birth, and SLE have been previously reported although these have been based on phenotypic correlations69–71. The majority of these traits (with the exception of age at first birth and systemic lupus erythematosus) demonstrated rG of a
