ROIs. In contrast, very few such connections were increased in patients relative to controls (1 of 12 for left mTLE, 0 of 9 for right mTLE). Specifically, controls show strong interhemispheric connectivity between bilateral retrosplenial cortices and hippocampi, whereas patients with mTLE only had weak connectivity between these ROIs. Second, patients with mTLE showed a distinct pattern that was characterized by stronger intrahemispheric, anterior–posterior connectivity than healthy controls. Especially striking was the increased functional connectivity involving the ROIs situated in the prefrontal cortices. This was present in 7 out of 12 increased connections in left mTLE and only 2 of 23 increased connections for controls. A similar pattern was seen for right mTLE (5 of 9 connections) compared to controls (0 of 15 connections).
