The Collaborative Study on the Genetics of Alcoholism (COGA) (Begleiter et al., 1995; Nurnberger et al., 2004; Schuckit et al., 2018) includes probands meeting criteria for alcohol dependence, their family members, and community control families. There were 7,645 participants of European ancestry with genotype data available as well as data on alcohol-related phenotypes; of these, 6,850 were ≥20 years (the mean age of onset of alcohol dependence) and reported lifetime alcohol use.
