We further employed a process of network merging to uncover the most important relationships between 120h DE genes and their associated microRNAs dysregulated during 0 and 8h time points. For each brain region, the top 3 networks obtained from the "0hDEmiR/120hDEtargets" and "8hDEmiR/120hDEtargets" datasets were combined, expanding component gene families or complexes to include all members present in the dataset (S3 Fig). Genes DE at 120h and common to these 2 merged networks are given in Table 5. Using the time point-based microRNA-mRNA relationships, we identified potential dysregulated microRNA regulators of these critical network genes (Fig 8).
