Chunk #35 — Online Methods (Limit 3,000 words, at end of manuscript, currently 2,064) — Building gene expression prediction databases

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.

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All SNPs within the cis-region (+/− 1 Mb) of each gene were included in the regression analysis. Accuracy of prediction was estimated by comparing predicted expression to measured expression, across all 10 cross-validation folds; this correlation was termed cross-validation R2 or Rcv2. Genes with Rcv2 > 0.01 (~p < 0.05) were included in our final predictor database.