We curated the most recent European ancestry GWAS summary data for 11 major psychiatric disorders: attention-deficit/hyperactivity disorder (ADHD)14, problematic alcohol use (ALCH)15, anorexia nervosa (AN)16, autism spectrum disorder (AUT)17, anxiety disorders (ANX)18,19, bipolar disorder (BIP)20, major depressive disorder (MDD)21,22, obsessive compulsive disorder (OCD)23, post-traumatic stress disorder (PTSD)24,25, schizophrenia (SCZ)26, and Tourette syndrome (TS)27 (Table 1 and Supplementary Table 1). A heatmap of genetic correlations estimated using LD Score regression (LDSC)8 indicates pervasive overlap across the 11 disorders, with more pronounced clustering observed among certain constellations of disorders (Fig. 1a and Supplementary Table 2).
