For the overall de novo mutation rate (i.e., coding plus non-coding variants), we considered all variants identified within the total callable (exome + other) interval. For coding mutation rate (e.g., Table 2; Figures 2A, 2B, 3A, and 3B), we applied the same approach with the total callable exome. This strategy normalizes for differences in capture array design and coverage distribution across the exome and precisely estimates coding mutation rate.
